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Giant ulcers (>3 cm in size)reveal a higher risk of complications such as bleeding and per-foration (Levine 2008a). As mentioned earlier,phenotypic changes that are associated with the conversion process (naive/antigen specific Tcell to Treg and Treg to helper T cell) are simply the expression of FOXP3 (naive/antigenspecific T cell to Treg) or the loss of expression (Treg and Treg to helper T cell)

As mentioned earlier,phenotypic changes that are associated with the conversion process (naive/antigen specific Tcell to Treg and Treg to helper T cell) are simply the expression of FOXP3 (naive/antigenspecific T cell to Treg) or the loss of expression (Treg and Treg to helper T cell).

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